This is an important contribution, adding to the understanding of bone remodeling, which is not just relevant to arthritis but also to degenerative bone changes. Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture. Whereas degenerative osteoarthritis results in the formation of new . Figure 3 New bone formation next to inflamed joints is increased upon blockade of DKK (a) Microphotographs of toluidine blue–stained joint sections of, ”from.

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Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice.

Dickkopf-1 is a master regulator of joint remodeling – Semantic Scholar

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. By inhibiting Dickkopf-1 DKK-1a regulatory molecule of the Wnt pathway, we were able to reverse the bone-destructive pattern of a mouse model of rheumatoid arthritis to the bone-forming pattern of osteoarthritis. Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid arthritis leads to bone resorption.

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Recommendations for the management of secondary hypogammaglobulinaemia due to B cell targeted therapies in autoimmune rheumatic diseases. Migrating cells were constructed by scratching with a pipette tip, whereas stationary cells were not applied by scratching. Scale bar, 40 mm.

Recently, Shelef et al. Certain parts of this website offer the opportunity for users to dickkopc-1 opinions, information and material including without limitation academic papers and data ‘Material’ in areas of the website. Circulating dickkopf-1 and radiological progression in patients with early rheumatoid arthritis treated with etanercept. This up-regulation was confirmed on uoint protein level by fluorescence microscopy supplementary Fig.


S2available at Rheumatology Online. Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid arthritis leads to bone resorption. These results suggest that the Wnt pathway is a key regulator of joint remodeling. A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody.

Integrins are cell surface adhesion receptors that link the cell surface to the extracellular matrix ECM or to other cells. FPrime is an expert-curated resource to help you find the articles of greatest interest and relevance to you.

Classified as close New Finding 4. These discrepancies might result from the variety of diseases and cellular conditions that regukator been studied. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License.

Bone Tissue pediatric intracranial germ cell brain tumor. PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis.

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Black arrows indicate areas of proteoglycan deposition.

Dickkopf-1 is a master regulator of joint remodeling.

Paxillin, a focal adhesion adaptor protein, is regulated regulatof c-Jun amino-terminal kinase JNK —mediated phosphorylation and is an essential player in the regulation of cell migration [ 2021 ]. Moreover, the distances between the migration fronts of control and SPtreated RA FLSs were also significantly different at 6, 24 and 48 h.

The use of certain tools provided by this joiht is subject to additional Masher and Conditions. Rheumatoid arthritis progression mediated by activated synovial fibroblasts.


The dickmopf-1 of integrins to ECM proteins activates diverse non-receptor protein tyrosine kinase signalling pathways, including the FAK, c-Src and Syk pathways.

We identified tumor necrosis factor-alpha TNF as a key inducer of DKK-1 in the mouse inflammatory arthritis model and in human rheumatoid arthritis. By posting or uploading Material you warrant and represent that: Disclosures Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality.

Conflicting results regarding the role of DKK-1 in cell migration have been described in different cell types, including hepatocellular carcinoma cells [ 13 ], intestinal epithelial cells [ 14 ], HEK cells [ 15 ] and thyroid cancer cells [ 16 ].

Dickkopf-1 is a master regulator of joint remodeling

Osteophyte tumor necrosis Neurodegenerative Disorders Bone Resorption. They were all female patients and provided written informed consent. I am an author of this article. HolmenTroy A. Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.

Dickkopf-1 stimulates fibroblast-like synoviocyte migration through Janus kinase activation [abstract]. Related articles in PubMed Signal transmission at invaginating cone photoreceptor synaptic contacts following deletion of the presynaptic cytomatrix protein Bassoon in mouse retina. From This Paper Figures, tables, and topics from this paper.

Wound scratching was used to induce the migration of FLSs [ 26 ]. Consistent with the gene expression data, western blot analysis showed a high level of DKK-1 protein expression at 24 h after wound scratching, whereas a lower level of DKK-1 protein was produced in OA FLSs. Register for day free trial Registration is free and only takes a moment, or subscribe for unlimited access. F reserves the right to remove any comments that it considers in its absolute discretion to be inappropriate, offensive or otherwise in breach of the Terms and Conditions relating to Materials including Comments.

Add comment Close comment form modal. Rheumatoid Arthritis Search for additional papers on this topic. Wound scratch assays were performed to assess FLS migration. You are an Editor for the journal in which the article is published.